BindingDB BDBM50536678 CHEMBL4550702

BDBM50536678 CHEMBL4550702

SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)NCC(F)(F)F

InChI Key InChIKey=UEFCSGDOOJJXTN-UHFFFAOYSA-N

Data 100 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50536678

Mitogen-activated protein kinase 8(Homo sapiens (Human))
Merck And

Curated by ChEMBL

BDBM50536678(CHEMBL4550702)

IC50: 1.80E+4nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K8 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Mitogen-activated protein kinase 8(Homo sapiens (Human))
Merck And

Curated by ChEMBL

BDBM50536678(CHEMBL4550702)

IC50: 2.40E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK8 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Filter my 100 hits

Targets 99▿
- Mitogen-activated protein kinase 8 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase JAK1 1
- Receptor tyrosine-protein kinase erbB-2 1
- Hepatocyte growth factor receptor 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Serine/threonine-protein kinase B-raf 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Serine/threonine-protein kinase Nek6 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek2 1
- Sphingosine kinase 1 1
- MAP/microtubule affinity-regulating kinase 3 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- MAP/microtubule affinity-regulating kinase 4 1
- Tyrosine-protein kinase JAK2 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Tyrosine-protein kinase ZAP-70 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase Sgk1 1
- Ephrin type-A receptor 3 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ITK/TSK 1
- Insulin-like growth factor 1 receptor 1
- Epidermal growth factor receptor 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Ribosomal protein S6 kinase beta-1 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Cyclin-dependent kinase 2 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 2 1
- Ephrin type-A receptor 8 1
- MAP kinase-activated protein kinase 5 1
- Death-associated protein kinase 1 1
- PAS domain-containing serine/threonine-protein kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Beta-adrenergic receptor kinase 1 1
- Cyclin-dependent kinase 7 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase TAO2 1
- Testis-specific serine/threonine-protein kinase 1 1
- Angiopoietin-1 receptor 1
- Mast/stem cell growth factor receptor Kit 1
- Serine/threonine-protein kinase MRCK alpha 1
- Protein-tyrosine kinase 6 1
- Mitogen-activated protein kinase 14 1
- Activin receptor type-1B 1
- Casein kinase II subunit alpha 1
- Cyclin-dependent kinase 5 activator 1 1
- Interleukin-1 receptor-associated kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Mitogen-activated protein kinase 1 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Tyrosine-protein kinase Lck 1
- NT-3 growth factor receptor 1
- Mitogen-activated protein kinase 9 1
- G protein-coupled receptor kinase 4 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Serine/threonine-protein kinase N1 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-3 1
- Serine/threonine-protein kinase TBK1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Fibroblast growth factor receptor 2 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Mitogen-activated protein kinase 13 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Macrophage colony-stimulating factor 1 receptor 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase Chk1 1
- SRSF protein kinase 1 1
Publications 1▿
- Bioorg Med Chem Lett 26: 4362-6 (2016) 100
Institutions 1▿
- Merck And 100
Affinity: 6 to 1.0E+5 nM▿
- IC50 100
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0